A high concept thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.The transformation has begun in season two. New York City is falling to an evil epidemic and no one is coming to its rescue. Its citizens must fight or die. Now Eph and Dr. Martinez concentrate on creating a biological weapon, while Setrakian searches for an ancient book he hopes will reveal the strigoi's history...and possibly a way to kill them.